Efficacy of an MFGM-enriched complementary food in diarrhea, anemia, and micronutrient status in infants.
J Pediatr Gastroenterol Nutr
; 53(5): 561-8, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21637131
ABSTRACT
OBJECTIVE:
The aim of the present study was to evaluate the efficacy of a milkfat globule membrane (MFGM)-enriched protein fraction in a complementary food, on diarrhea, anemia, and micronutrient status. SUBJECTS ANDMETHODS:
A randomized, double-blind controlled design to study 550 infants, 6 to 11 months old, who received daily for 6 months a complementary food (40 g/day) with the protein source being either the MFGM protein fraction or skim milk proteins (control). Health and nutritional status of infants were examined monthly in the outpatient clinic; product intake, food patterns, and diarrhea morbidity were assessed by home visits twice per week. Hemoglobin and micronutrient status were measured at 0 and 6 months of intervention. Results are presented as the entire group and as 6 to 8 and 9 to 11 months subgroups.RESULTS:
A total of 499 infants completed the study. Global prevalence of diarrhea was 3.84% and 4.37% in the MFGM group and control group, respectively (P < 0.05). Consumption of the MFGM protein fraction reduced episodes of bloody diarrhea (odds ratio 0.54; 95% confidence interval 0.31-0.93, P = 0.025) adjusting for anemia and potable water facilities as covariates. There were no differences between groups in anemia, serum ferritin, zinc, or folate.CONCLUSIONS:
Addition of an MFGM-enriched protein fraction to complementary food had beneficial effects on diarrhea in infants and may thus help to improve the health of vulnerable populations.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Alimentos Fortificados
/
Anemia Ferropriva
/
Micronutrientes
/
Diarreia
/
Fenômenos Fisiológicos da Nutrição do Lactente
/
Proteínas do Leite
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
America do sul
/
Peru
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Ano de publicação:
2011
Tipo de documento:
Article