Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma.
Bioorg Med Chem
; 19(13): 4057-66, 2011 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-21641806
ABSTRACT
Folate (FOL) mediated poly-lactide-co-glycolide-polyethylene glycol nanoparticles (FOL-PEG-PLGA NPs) bearing paclitaxel (PTX) were prepared for the effective delivery of drug to endometrial carcinoma. The average size, zeta potential and encapsulation efficiency of FOL-targeted NPs were found to be around 220 nm, -30.43 mV and 95.6%. Cellular uptake was observed. The accumulation of FOL-targeted NPs depends on dual effects of passive and active targeting. The FOL-targeted PTX NPs showed a greater cytotoxicity against HEC-1A cancer cells in vitro and in vivo, which might be induced by apoptosis. H&E staining did not showed apparent tissue damage to liver and kidney of the mice after injecting NPs intravenously. These results suggest that the novel FOL-PEG-PLGA NPs could be a potential delivery system with excellent therapeutic efficacy for targeting the drugs to cancer cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
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Portadores de Fármacos
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Neoplasias do Endométrio
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Paclitaxel
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Ácido Láctico
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Nanopartículas
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Ácido Fólico
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Antineoplásicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2011
Tipo de documento:
Article