Assessment of the potential malignancy of Epstein-Barr virus (EBV)-infected B cells in AIDS-related disorders.
Cancer Detect Prev
; 14(3): 325-9, 1990.
Article
em En
| MEDLINE
| ID: mdl-2167168
ABSTRACT
Spontaneous lymphoblastoid cell lines (LCLs) were established from the peripheral blood of ten human immunodeficiency virus (HIV)-seropositive patients in order to investigate whether or not a progression of the cells toward a malignant state could be traced. The LCLs studied displayed no differences in their surface phenotype, karyotype, or tumorigenicity in nude mice when compared with a wide panel of control LCLs. However, four of the ten LCLs derived from HIV-seropositive patients formed colonies in agar with a cloning efficiency (0.1 to 0.9%) that was much lower than that of a control neoplastic B cell line (50%). Some sublines that were derived form the agar colonies expressed new activation markers (CD10 and Bac-1) but did not produce tumors in nude mice or display chromosomal abnormalities. These sublines might comprise cells that have progressed toward a more transformed state.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Transformação Celular Viral
/
Soropositividade para HIV
/
Herpesvirus Humano 4
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Detect Prev
Ano de publicação:
1990
Tipo de documento:
Article