Inherited IgA glycosylation pattern in IgA nephropathy and HSP nephritis: where do we go next?
Kidney Int
; 80(1): 8-10, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21673733
ABSTRACT
New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schönlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasculite por IgA
/
Imunoglobulina A
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Glomerulonefrite por IGA
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Nefrite Hereditária
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2011
Tipo de documento:
Article