Molecules and roles of mitochondrial calcium signaling.
Biofactors
; 37(3): 219-27, 2011.
Article
em En
| MEDLINE
| ID: mdl-21674643
ABSTRACT
Mitochondrial Ca(2+) homeostasis is an important component of the calcium-mediated cellular response to extracellular stimuli. It controls key organelle functions, such as aerobic metabolism and the induction of apoptotic cell death, and shapes the spatiotemporal pattern of the cytosolic [Ca(2+)] increase. We here summarize both the main roles of Ca(2+) signals within mitochondria and the emerging molecular information that is starting to unravel the composition of the signaling apparatus and reveal potential pharmacological targets in this process of utmost pathophysiological relevance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinalização do Cálcio
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biofactors
Ano de publicação:
2011
Tipo de documento:
Article