Graft loss risk in renal transplant recipients with metabolic syndrome: subgroup analyses of the ALERT trial.
J Nephrol
; 25(2): 245-54, 2012.
Article
em En
| MEDLINE
| ID: mdl-21725919
ABSTRACT
BACKGROUND:
Several nonimmunologic risk factors for late renal graft loss (RGL) are also known components of metabolic syndrome (MS). We aimed to study MS as a risk factor for RGL. Also, the effect of statin treatment in reducing renal risk in renal transplant recipients (RTRs) with MS was studied.METHODS:
Nondiabetic RTRs (n=1,706) from the ALERT trial were followed for 7-8 years. MS was defined according to National Cholesterol Education Program Adult Treatment Panel III definition with waist girth replaced by BMI ≥30 (calculated as kg/m(2)). Renal end points included death-censored RGL and graft loss or doubling of serum creatinine.RESULTS:
During the follow-up, 284 patients experienced RGL, and there were 343 cases of graft loss or doubling of serum creatinine. Those with MS had increased risk for RGL (relative risk = 1.28, 95% confidence interval, 1.00-1.63; p=0.047), but not for the combined end point. After adjustment for other known and potential risk factors, MS was no longer associated with increased risk for RGL. The association between MS and RGL risk was attenuated once adjustment for creatinine was made. Statin treatment did not reduce the risk for renal end points in RTRs with or without MS.CONCLUSION:
MS had no independent association with RGL risk. Adjustment for renal function attenuated the association between MS and RGL.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Monoinsaturados
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Transplante de Rim
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Síndrome Metabólica
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Sobrevivência de Enxerto
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Indóis
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Nephrol
Ano de publicação:
2012
Tipo de documento:
Article