Your browser doesn't support javascript.
loading
Chronic kidney disease of unknown aetiology in Sri Lanka: is cadmium a likely cause?
Wanigasuriya, Kamani P; Peiris-John, Roshini J; Wickremasinghe, Rajitha.
Afiliação
  • Wanigasuriya KP; Department of Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. kamaniw@sltnet.lk
BMC Nephrol ; 12: 32, 2011 Jul 05.
Article em En | MEDLINE | ID: mdl-21726464
BACKGROUND: The rising prevalence of chronic kidney disease (CKD) and subsequent end stage renal failure necessitating renal replacement therapy has profound consequences for affected individuals and health care resources. This community based study was conducted to identify potential predictors of microalbuminuria in a randomly selected sample of adults from the North Central Province (NCP) of Sri Lanka, where the burden of CKD is pronounced and the underlying cause still unknown. METHODS: Exposures to possible risk factors were determined in randomly recruited subjects (425 females and 461 males) from selected areas of the NCP of Sri Lanka using an interviewer administered questionnaire. Sulphosalicylic acid and the Light Dependent Resister microalbumin gel filtration method was used for initial screening for microalbuminuria and reconfirmed by the Micral strip test. RESULTS: Microalbumnuria was detected in 6.1% of the females and 8.5% of the males. Smoking (p < 0.001), alcohol use (p = 0.003), hypertension (p < 0.001), diabetes (p < 0.001), urinary tract infection (UTI) (p = 0.034) and consumption of water from wells in the fields (p = 0.025) were associated with microalbuminuria. In the binary logistic regression analysis, hypertension, diabetes mellitus, UTI, drinking well water in the fields, smoking and pesticide spraying were found to be significant predictors of microalbuminuria. CONCLUSIONS: Hypertension, diabetes mellitus, UTI, and smoking are known risk factors for microalbuminuria. The association between microalbuminuria and consumption of well water suggests an environmental aetiology to CKD in NCP. The causative agent is yet to be identified. Investigations for cadmium as a potential causative agent needs to be initiated.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 12_ODS3_hazardous_contamination / 2_ODS3 Base de dados: MEDLINE Assunto principal: Cádmio / Intoxicação por Cádmio / Exposição Ambiental / Falência Renal Crônica Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: BMC Nephrol Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 12_ODS3_hazardous_contamination / 2_ODS3 Base de dados: MEDLINE Assunto principal: Cádmio / Intoxicação por Cádmio / Exposição Ambiental / Falência Renal Crônica Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: BMC Nephrol Ano de publicação: 2011 Tipo de documento: Article