[Change in adenyl cyclase activity in the differentiation of neuroblastoma cells]. / Anderung der Adenylcyclase-Aktivität während der Differenzierung von Neuroblastomzellen.
Onkologie
; 13(4): 301-4, 1990 Aug.
Article
em De
| MEDLINE
| ID: mdl-2172886
ABSTRACT
The change of Adenylcyclase from the plasma membrane of neuroblastoma cells during cell differentiation was investigated. As a parameter for the change of the Adenylcyclase activity we determined the Adenylcyclase stimulatability caused by the neurotransmitters noradrenaline, dopamine and adrenaline. In differentiated neuroblastoma cells the basilar Adenylcyclase activity was higher than in undifferentiated cells. The tested neurotransmitters showed the same result. By means of a G-protein from medullary adrenal gland we succeeded in reconstructing the Adenylcyclase from both undifferentiated and differentiated cells. The importance of the Gs protein for the cell differentiation is discussed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Tumorais Cultivadas
/
Diferenciação Celular
/
Adenilil Ciclases
/
Neuroblastoma
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
De
Revista:
Onkologie
Ano de publicação:
1990
Tipo de documento:
Article