Abnormalities in cholesterol metabolism cause peripheral neuropathy and dementia in AIDS--a hypothesis.
Med Hypotheses
; 33(1): 57-61, 1990 Sep.
Article
em En
| MEDLINE
| ID: mdl-2175010
ABSTRACT
The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may be caused by dysfunction of cellular cholesterol transport. Substitution of high density lipoprotein is recommended in the treatment of severe polyneuropathy and dementia in AIDS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colesterol
/
Complexo AIDS Demência
/
Síndrome da Imunodeficiência Adquirida
/
Doenças do Sistema Nervoso Periférico
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Med Hypotheses
Ano de publicação:
1990
Tipo de documento:
Article