Potential role of nuclear factor κB in diabetic cardiomyopathy.
Mediators Inflamm
; 2011: 652097, 2011.
Article
em En
| MEDLINE
| ID: mdl-21772665
ABSTRACT
Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
NF-kappa B
/
Cardiomiopatias Diabéticas
Limite:
Humans
Idioma:
En
Revista:
Mediators Inflamm
Ano de publicação:
2011
Tipo de documento:
Article