[Therapeutic efficacy of Triazavirin, a novel Russian chemotherapeutic, against influenza virus A (H5N1)].
Antibiot Khimioter
; 56(1-2): 10-2, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-21780665
ABSTRACT
Therapeutic activity of Triazavirin against experimental influenza A was studied on albino mice intranazally infected with influenza virus A/Chicken/Kurgan/Russia/02/05 (H5N1) vs. reference drugs (Oseltamivir, Remantadin and Arbidol). The study showed that in a therapeutic dose of 1 mg/kg Triazavirin was efficient in protection of the animals from death. Its protective therapeutic efficacy (36.7+/-1.7%) was close to that of Oseltamivir (50.0+/-0.0%), comparable with that of Remantadin (38.3+/-1.7%) and higher than that of Arbidol (11.7+/-1.7%). During the whole observation period (up to the terminal phase) Triazavirin inhibited the influenza virus A accumulation in the lungs of the infected albino mice by more than 3 lg.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Azóis
/
Triazinas
/
Influenza Humana
/
Virus da Influenza A Subtipo H5N1
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
/
Europa
Idioma:
Ru
Revista:
Antibiot Khimioter
Ano de publicação:
2011
Tipo de documento:
Article