Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity.
J Laryngol Otol
; 125(8): 786-94, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21781353
ABSTRACT
BACKGROUND:
High sodium salicylate doses can cause reversible hearing loss and tinnitus, possibly due to reduced outer hair cell electromotility. Sodium salicylate is known to alter outer hair cell structure and function. This study determined the reversibility and cochlear recovery time after administration of an ototoxic sodium salicylate dose to guinea pigs with normal cochlear function. STUDYDESIGN:
Prospective experimental investigation.METHODS:
All animals received a single 500 mg sodium salicylate dose, but with different durations of action. Function was evaluated before drug administration and immediately before sacrifice. Cochleae were processed and viewed using scanning electron microscopy.RESULTS:
Changes in outer hair cell function were observed to be present 2 hours after drug administration, with recovery of normal anatomy beginning after 24 hours. Subsequently, derangement and distortion of cilia reduced, with effects predominantly in row three. At 168 hours, cilia were near-normal but with mild distortions which interfered with normal cochlear physiology.CONCLUSIONS:
Ciliary changes persisted for up to 168 hours after ototoxic sodium salicylate administration.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Salicilato de Sódio
/
Anti-Inflamatórios não Esteroides
/
Células Ciliadas Auditivas Externas
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Recuperação de Função Fisiológica
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Perda Auditiva
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
J Laryngol Otol
Ano de publicação:
2011
Tipo de documento:
Article