The use of streptolysin O (SLO) as an adjunct therapy for Rhodococcus equi pneumonia in foals.
Vet Microbiol
; 154(1-2): 156-62, 2011 Dec 29.
Article
em En
| MEDLINE
| ID: mdl-21798675
ABSTRACT
Rhodococcus equi is a soil borne bacterium that causes severe morbidity and death in young foals. The economic costs of the disease include loss of life, treatment expenses, veterinary monitoring expenses and, perhaps most importantly, potential reduction in future athletic performance in horses that suffer severe lung abscessations caused by R. equi. Current standard of care for pneumonia caused by R. equi is treatment with a macrolide antimicrobial and rifampicin. However, the hallmark of pneumonia caused by R. equi is severe formation of pyogranulomas and a walling off effect that can prevent systemic antibiotics from reaching antimicrobial concentrations in lung tissues. It is hypothesized that streptolysin O (SLO) used as an adjunct therapy with antibiotics will reduce the duration and severity of disease caused by R. equi pneumonia compared to antibiotic therapy alone. Addition of SLO to the antibiotic enhanced clinical responses compared to the other groups, including the antibiotic alone group. Of particular significance were lower bacterial counts in the lungs and longer survival time in those foals treated with SLO and antibiotics.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
4_TD
/
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Estreptolisinas
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Infecções por Actinomycetales
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Pneumonia Bacteriana
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Doenças dos Cavalos
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Cavalos
Limite:
Animals
Idioma:
En
Revista:
Vet Microbiol
Ano de publicação:
2011
Tipo de documento:
Article