Radiological progression in rheumatoid arthritis: do D-penicillamine and hydroxychloroquine have different effects?
Br J Rheumatol
; 29(2): 126-7, 1990 Apr.
Article
em En
| MEDLINE
| ID: mdl-2182170
ABSTRACT
We studied 43 patients with active rheumatoid disease of less than 4 years' duration 23 were given hydroxychloroquine and 20 penicillamine. Efficacy was assessed using clinical and laboratory variables. Radiological progression was measured using Larsen's method for scoring plain radiographs of the hands and feet. Twenty-four patients received 2 years' continuous therapy. Clinically both drugs were effective with falls in articular index and C-reactive protein. Initial radiological damage was less with penicillamine (P less than 0.05 by Wilcoxon rank sum test). By 2 years there were no significant differences between the two drugs; mean increases in Larsen score were 20.3 with penicillamine and 27.5 with hydroxychloroquine. Both groups progressed at a rate likely to give severe joint destruction over 10-20 years.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilamina
/
Artrite Reumatoide
/
Hidroxicloroquina
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Rheumatol
Ano de publicação:
1990
Tipo de documento:
Article