The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma.
Clin Exp Dermatol
; 36(7): 788-92, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21883393
ABSTRACT
BACKGROUND:
Distinguishing keratoacanthoma (KA) from well-differentiated squamous cell carcinoma (SCC) is sometimes difficult. Recent evidence indicates that the nuclear factor kappa B p50 subunit (p50) and cortactin might be useful to distinguish between these two conditions.AIM:
To verify whether p50 and cortactin are useful differentiation markers to distinguish between subungual KA and well-differentiated SCC.METHODS:
Immunohistochemistry using p50, cortactin and Ki-67 was performed on 20 patients with KA and 20 patients with facial well-differentiated SC. Ki-67 staining was also evaluated and scored.RESULTS:
Both p50 and cortactin had higher levels of expression in KA than in SCC. Both were localized to the basal-cell layer of KA, whereas they were scattered without polarity throughout the SCC lesions. Although the Ki-67 index was not significantly different between KA and SCC, the staining pattern also showed loss of polarity in SCC.CONCLUSION:
p50 and cortactin might be useful makers to distinguish between KA and well-differentiated SCC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Neoplasias Faciais
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Carcinoma de Células Escamosas
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Biomarcadores Tumorais
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Cortactina
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Subunidade p50 de NF-kappa B
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Ceratoacantoma
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2011
Tipo de documento:
Article