Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver.
Biosci Biotechnol Biochem
; 75(9): 1668-76, 2011.
Article
em En
| MEDLINE
| ID: mdl-21897050
ABSTRACT
We determined the effects of a green tea extract with 36% alcohol on the blood alcohol content, oxidative stress, lipogenesis, inflammation and liver function of female Wistar rats. Tea alcohol significantly decreased the O2â», H2O2 and HOCl amounts via catechins and not caffeine. Thirty days of alcohol gavage improved the level of reactive oxygen species (ROS) in the liver, bile and blood, increased the 4-hydroxynonenal-protein adducts, Kupffer cell infiltration and lipid accumulation in the liver, and elevated the plasma alanine aminotransferase level. A western blot analysis showed reduced expression of the oxidative enzymes (CYP2E1 and NADPH oxidase p47phox protein) and lipogenic enzymes (SREBP-1c and fatty acid synthase) in the alcohol-treated liver. Tea alcohol significantly attenuated these elevated parameters. We conclude that the green tea extract in alcohol efficiently reduced the amounts of O2â», H2O2 and HOCl primarily due to the catechin content, and not caffeine. The developed tea liquor attenuated alcohol-induced oxidative injury and lipogenesis in the liver by the synergetic action of catechins and caffeine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chá
/
Consumo de Bebidas Alcoólicas
/
Extratos Vegetais
/
Catequina
/
Etanol
/
Lipogênese
/
Fígado
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Ano de publicação:
2011
Tipo de documento:
Article