Betamethasone effects on umbilical arteries and ductus venosus Doppler velocity waveforms in growth-restricted fetuses.
J Matern Fetal Neonatal Med
; 25(7): 1179-82, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-21923610
ABSTRACT
UNLABELLED We studied intrauterine-growth-restricted (IUGR) fetuses with absent or reversed umbilical artery end-diastolic flow (EDF) velocity in order to evaluate the benefit of antenatal steroid therapy. Perinatal outcomes after betamethasone were evaluated where end diastolic flow returned (group I), compared with data from fetuses with persistent absent-reverse end diastolic(ARED) flow (group II). OBJECTIVES/METHODS:
We recruited sixty-four IUGR fetuses, 28-32 weeks' gestation, whose umbilical artery spectral tracings showed ARED flow and positive a-wave in the ductus venosus at admission.RESULTS:
Group I, 21 cases of restored EDF after betamethasone Significant, persistent return of umbilical artery EDF flow and persistent ductus venosus a-wave were documented. Group II, 43 cases of persistent ARED flow Persistent ARED flow in umbilical arteries and deterioration of ductus venosus waveform with significant, increasing pulsatility index and/or a-wave disappearance were documented. In group I, cardiotocographic alterations were delayed contrasted with group II, (p = 0.03). Neonatal complications in group II were eight cases of intraventricular hemorrhage; two cases of retinopathy of prematurity; three neonatal deaths, one fetal demise; and a higher incidence of neonatal respiratory distress syndrome.CONCLUSIONS:
Betamethasone treatment may have beneficial effects on restoring end-diastolic umbilical artery velocimetry and precordial waveforms. These spectral Doppler changes are related to delayed cardiotocographic alterations and to better perinatal outcomes.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Base de dados:
MEDLINE
Assunto principal:
Fluxo Sanguíneo Regional
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Artérias Umbilicais
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Betametasona
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Retardo do Crescimento Fetal
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Glucocorticoides
Limite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Ano de publicação:
2012
Tipo de documento:
Article