A one-pot preparation of N-2-mercaptobenzoyl-amino amides.
Tetrahedron Lett
; 52(32): 4103-4105, 2011 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-21931465
ABSTRACT
The HIV-1 nucleocapsid (NCp7), structurally defined by zinc-binding domains, participates in crucial stages of the HIV-1 lifecycle and is mutationally nonpermissive, making it an attractive anti-HIV target. Mode of action studies have shown that the secondary structure and activity of NCp7 can be disrupted by acyl transfer from N-2-mercaptobenzoyl-amino amides. We have developed an improved one-pot reaction that affords N-2-mercaptobenzoyl-amino acids on multi-gram scales. This synthetic route allows for rapid modular construction and has greatly expanded the scope of easily accessible potential NCp7 inhibitors.
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01-internacional
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MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2011
Tipo de documento:
Article