A high body mass index in esophageal cancer patients does not influence postoperative outcome or long-term survival.
Ann Surg Oncol
; 19(3): 766-71, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-21979112
ABSTRACT
BACKGROUND:
The body mass index (BMI) in the general population has increased over the past decades. A high BMI is a known risk factor for the development of esophageal adenocarcinoma. Several studies on the influence of a high BMI on the postoperative course and survival after esophagectomy have shown contradictory results. The aim of the present study was to determine the influence of a high BMI on postoperative complications and survival among a large cohort of esophageal cancer patients.METHODS:
Patients who underwent an esophagectomy between 1993 and 2010 were divided into three groups according to their BMI normal weight (<25 kg/m(2)), overweight (25-30 kg/m(2)) or obese (≥ 30 kg/m(2)). Severity of complications was scored according to the Dindo classification, which was divided into three categories no complications, minor to moderate complications, and severe complications. Long-term survival was determined according to the Kaplan-Meier method.RESULTS:
A total of 736 esophagectomy patients were divided into three groups normal weight (n = 352), overweight (n = 308), and obese (n = 72). Complications rates were similar for all groups (65-72%, P = 0.241). The incidence of anastomotic leakage was higher among obese patients compared to the other groups (20% vs. 10-12% respectively, P = 0.019), but there was no significant difference between the three groups regarding the severity of complications according to the Dindo classification (P = 0.660) or in 5-year survival rates (P = 0.517).CONCLUSIONS:
A high BMI is not associated with an increased incidence or severity of complications after esophagectomy; however, anastomotic leakage occurred more frequently in obese patients. Five-year survival rates were not influenced by the preoperative BMI. A high BMI is therefore ought not be an exclusion criterion for esophagectomy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Neoplasias Esofágicas
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Índice de Massa Corporal
/
Esofagectomia
/
Obesidade
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ann Surg Oncol
Ano de publicação:
2012
Tipo de documento:
Article