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A pilot study on the association between double positive Chlamydia pneumoniae serology and serum lipid indices alterations in obese adult females.
Jaworowska, Agnieszka; Bazylak, Grzegorz.
Afiliação
  • Jaworowska A; Department of Pharmaco-Bromatology & Molecular Nutrition, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Life Sci ; 89(23-24): 854-61, 2011 Dec 05.
Article em En | MEDLINE | ID: mdl-21983298
AIMS: To study the relationship between Chlamydia pneumoniae serologic status and serum lipid abnormalities in apparently healthy obese female subjects living in urban areas. MAIN METHODS: Serum samples from 117 apparently healthy females (mean age 50 years), classified as overweight/obese (OW/OB,n=74) or normal weight (NW,n=43) according to their body mass index (BMI), were tested for specific IgG and IgA antibodies against C. pneumoniae using ELISA assay. Serum triglycerides (TG), total cholesterol (TChol) and high-density lipoprotein cholesterol (HDLChol) concentrations were measured using enzymatic methods. Serum low-density lipoprotein cholesterol (LDLChol) was calculated using the Friedewald formula. Lifestyle data for all subjects were collected using a validated self-reported questionnaire. KEY FINDINGS: The prevalence of C. pneumoniae infection, as indicated by single positive serology (IgG(+) or IgA(+)), was significantly higher among the OW/OB females than the NW subjects (38.5%vs.27.0%,p=0.021). Females with double-positive serology (IgG(+)/IgA(+)) in the OW/OB group indicated significantly higher (p<0.05) mean serum TG, TChol and LDLChol levels compared to the double seronegatives (IgG(-)/IgA(-)) from this group. On the contrary, no statistical differences (p>0.05) were observed in these serum lipid indices between subjects in the NW group with considered opposite C. pneumoniae serology. Multivariate regression analysis on the 42 double-seropositive subjects, including both OW/OB and NW females and adjusted for such potential confounders as age, BMI and lifestyle factors, showed a significant association of double-positive C. pneumoniae serology with serum TG (ß=0.244;p=0.049),LDLChol (ß=0.332;p=0.037) and TChol-to-HDLChol ratio (ß=0.313;p=0.042). SIGNIFICANCE: These results suggest that possible chronic C. pneumoniae infection is a potential non-dietary factor in modification of the serum lipid profile in the adult OW/OB females.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chlamydophila pneumoniae / Infecções por Chlamydophila / Lipídeos / Obesidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Life Sci Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chlamydophila pneumoniae / Infecções por Chlamydophila / Lipídeos / Obesidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Life Sci Ano de publicação: 2011 Tipo de documento: Article