Spin-trapping reactions of a novel gauchetype radical trapper G-CYPMPO.
Anal Chem
; 83(24): 9600-4, 2011 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-22007796
ABSTRACT
Chemical reactions of a novel gauchetype spin trap, G-CYPMPO (sc-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-5-methy-1-pyrroline N-oxide, O1-P1-C6-N1 torsion angle = 52.8°), with reactive oxygen species were examined by pulse radiolysis technique with 35 MeV electron beam and by electron spin resonance spectroscopy after (60)Co γ-ray irradiation. The spin-trapping reaction rate constants of G-CYPMPO toward the hydroxyl radical and the hydrated electron were estimated to be (4.2 ± 0.1) × 10(9) and (11.8 ± 0.2) × 10(9) M(-1)s(-1), respectively. Half-lives of the spin adducts, hydroxyl radical, and perhydroxyl radical adducted G-CYPMPO were estimated to be â¼35 and â¼90 min, respectively. A comparison of the results with earlier reports using different radical sources suggests that the purity of the solution and/or the radical generation technique may influence the stability of the spin adducts.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peróxidos
/
Radical Hidroxila
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Detecção de Spin
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Óxidos N-Cíclicos
Idioma:
En
Revista:
Anal Chem
Ano de publicação:
2011
Tipo de documento:
Article