Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.
Bioorg Med Chem Lett
; 21(24): 7489-95, 2011 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-22047689
ABSTRACT
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
DNA Topoisomerases Tipo II
/
Dioxanos
/
Inibidores da Topoisomerase II
/
Antibacterianos
/
Naftiridinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2011
Tipo de documento:
Article