PGC-1 coactivators in the cardiovascular system.
Trends Endocrinol Metab
; 23(2): 90-7, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22047951
ABSTRACT
The beating heart consumes more ATP per weight than any other organ. The machineries required for this are many and complex. Fuel and oxygen must be transported via the vasculature, absorbed by cardiomyocytes, broken down, and regulated to match cellular demands. Much of this occurs in mitochondria, which comprise fully one third of cardiac mass. The PGC-1 proteins are transcriptional coactivators that have emerged as powerful orchestrators of these numerous processes, ensuring their proper coregulation in response to intracellular and extracellular cues. An important role for PGC-1s in cardiac function has been revealed over the past few years, and more recently interest in their role in the vasculature has been burgeoning. We review this literature, focusing on recent developments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Sistema Cardiovascular
/
Proteínas de Transporte
/
Coração
/
Proteínas de Choque Térmico
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Ano de publicação:
2012
Tipo de documento:
Article