Brassinosteroids and analogs as neuroprotectors: synthesis and structure-activity relationships.
Steroids
; 77(1-2): 91-9, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22064216
ABSTRACT
We have demonstrated previously that the brassinosteroid (BR) 24-epibrassinolide exerts neuroprotective effects deriving from its antioxidative properties. In this study, we synthesized 2 natural BRs and 5 synthetic analogs and analyzed their neuroprotective actions in neuronal PC12 cells, against 1-methyl-4-phenylpyridinium (MPP(+)), a neurotoxin known to induce oxidative stress and degenerescence of dopaminergic neurons characteristic of Parkinsonian brains. We also tested the neuroprotective potential of 2 commercially available BRs. Our results disclosed that 6 of the 9 BRs and analogs tested protected neuronal PC12 cells against MPP(+) toxicity. In addition, our structure-activity study suggests that the steroid B-ring and lateral chain play an important role for their neuroprotective action.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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1-Metil-4-fenilpiridínio
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Fármacos Neuroprotetores
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Neurônios Dopaminérgicos
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Brassinosteroides
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Antioxidantes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Steroids
Ano de publicação:
2012
Tipo de documento:
Article