Low serum vitamin D levels and recurrent inflammatory spinal cord disease.
Arch Neurol
; 69(3): 352-6, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22083799
ABSTRACT
BACKGROUND:
Low 25-hydroxyvitamin D levels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease.OBJECTIVE:
To investigate the association between low serum vitamin D levels and recurrent spinal cord disease. DESIGN, SETTING, AND PATIENTS We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25-hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord. MAIN OUTCOMEMEASURE:
Levels of 25-hydroxyvitamin D.RESULTS:
Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race.CONCLUSIONS:
This study provides a basis for a prospective trial of measuring 25-hydroxyvitamin D levels in these patient populations and assessing the influence of vitamin D supplementation on the frequency of relapses in those with recurrent inflammatory spinal cord disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Mielite
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
Idioma:
En
Revista:
Arch Neurol
Ano de publicação:
2012
Tipo de documento:
Article