Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction.
J Mater Sci Mater Med
; 23(1): 51-61, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22116662
ABSTRACT
The aim of this work was the morphological, physicochemical, mechanical and biological characterization of a new composite system, based on gelatin, gellan and hydroxyapatite, and mimicking the composition of natural bone. Porous scaffolds were prepared by freeze-drying technique, under three different conditions of freezing. The morphological analysis showed a homogeneous porosity, with well interconnected pores, for the sample which underwent a more rapid freezing. The elastic modulus of the same sample was close to that of the natural bone. The presence of interactions among the components was demonstrated through the physicochemical investigation. In addition, the infrared chemical imaging analysis pointed out the similarity among the composite scaffold and the natural bone, in terms of chemical composition, homogeneity, molecular interactions and structural conformation. Preliminary biological characterization showed a good adhesion and proliferation of human mesenchymal stem cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
/
Desenvolvimento Ósseo
/
Durapatita
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Substitutos Ósseos
/
Nanocompostos
/
Gelatina
Limite:
Humans
Idioma:
En
Revista:
J Mater Sci Mater Med
Ano de publicação:
2012
Tipo de documento:
Article