Determination of benzydamine and its N-oxide in biological fluids by high-performance liquid chromatography.
J Chromatogr
; 529(1): 113-23, 1990 Jul 13.
Article
em En
| MEDLINE
| ID: mdl-2211924
ABSTRACT
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine in plasma was 0.5 ng/ml and that in urine 1 ng/ml; the limit of reliable determination of benzydamine N-oxide in urine was 50 ng/ml. The method has been successfully applied to the analysis of these compounds in biological fluids after administration of intravenous and oral doses of benzydamine to human volunteers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzidamina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Chromatogr
Ano de publicação:
1990
Tipo de documento:
Article