Psoriasis and risk of nonfatal cardiovascular disease in U.S. women: a cohort study.
Br J Dermatol
; 166(4): 811-8, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-22175820
ABSTRACT
BACKGROUND:
Psoriasis has been linked to cardiovascular comorbidities in cross-sectional studies, but evidence regarding the association between psoriasis and incident cardiovascular disease (CVD) is limited.OBJECTIVES:
To make a prospective evaluation of the association between psoriasis and risk of incident nonfatal CVD.METHODS:
Participants (n = 96, 008) were included from the Nurses' Health Study II, and followed for 18 years. Information on physician-diagnosed psoriasis was obtained by self-report and diagnosis was confirmed by supplementary questionnaires. We included 2463 individuals with self-reported psoriasis and a subsample of 1242 with validated psoriasis. The main outcome was incident nonfatal CVD events [nonfatal myocardial infarction (MI) and nonfatal stroke], ascertained by biennial questionnaires and confirmed.RESULTS:
During 1 709 069 person-years of follow-up, 713 incident nonfatal CVD events were confirmed. Psoriasis was associated with a significantly increased multivariate-adjusted hazard ratio (HR) of nonfatal CVD, 1·55 [95% confidence interval (CI) 1·04-2·31]. HRs for nonfatal MI and stroke were 1·70 (95% CI 1·01-2·84) and 1·45 (95% CI 0·80-2·65), respectively. The association remained consistent in a sensitivity analysis of confirmed psoriasis (HR 2·06, 95% CI 1·31-3·26). For individuals with concomitant psoriatic arthritis, the risk of nonfatal CVD was even higher (HR 3·47; 95% CI 1·85-6·51). Women diagnosed with psoriasis at < 40 years of age or with duration of psoriasis ≥ 9 years had substantial elevations in CVD risk HR 3·26 (95% CI 1·21-8·75) and 3·09 (95% CI 1·15-8·29), respectively.CONCLUSIONS:
Psoriasis is an independent predictor for nonfatal CVD among women, with particularly high risk for those with longer duration of psoriasis and concomitant psoriatic arthritis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Doenças Cardiovasculares
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
2012
Tipo de documento:
Article