miRNAs in breast cancer tumorigenesis (Review).
Oncol Rep
; 27(4): 903-10, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-22200848
ABSTRACT
miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding mRNAs at the post-transcriptional level. It is estimated that in humans thousands of miRNAs are expressed and more than 700 miRNAs have been described to date. About 50% of annotated human miRNAs are detected in regions of fragile sites, which are associated with cancer. The available evidence has shown that miRNAs widely participate in the development or progression of many types of cancers, including breast cancer. The role of miRNAs in breast cancer has been widely investigated; here, we will focus on what is known about the working mechanism of miRNAs in different stages of breast cancer development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Regulação Neoplásica da Expressão Gênica
/
Transformação Celular Neoplásica
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MicroRNAs
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Oncol Rep
Ano de publicação:
2012
Tipo de documento:
Article