Imaging of seasonal affective disorder and seasonality effects on serotonin and dopamine function in the human brain.
Curr Top Behav Neurosci
; 11: 149-67, 2012.
Article
em En
| MEDLINE
| ID: mdl-22218931
ABSTRACT
According to current knowledge, disturbances in brain monoamine transmission play a major role in many psychiatric disorders, and many of the radioligands used for investigating these disorders bind to targets within the brain monoamine systems. However, a phylogenetically ancient and prevailing function of monoamines is to mediate the adaptation of organisms and cells to rhythmical changes in light conditions, and to other environmental rhythms, such as changes in temperature, or the availability of energy resources throughout the seasons. The physiological systems mediating these changes are highly conserved throughout species, including humans. Here we review the literature on seasonal changes in binding of monoaminergic ligands in the human brain. Moreover, we argue for the importance of considering possible effects of season when investigating brain monoamines in healthy subjects and subjects with psychiatric disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estações do Ano
/
Encéfalo
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Dopamina
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Serotonina
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Transtorno Afetivo Sazonal
Limite:
Humans
Idioma:
En
Revista:
Curr Top Behav Neurosci
Ano de publicação:
2012
Tipo de documento:
Article