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EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide.
Chen, Cheng; Xie, Xiao-Xia; Zhou, Qian; Zhang, Feng-Yi; Wang, Qiao-Ling; Liu, Ya-Qing; Zou, Yina; Tao, Qing; Ji, Xue-Mei; Yu, Shu-Qin.
Afiliação
  • Chen C; Jiangsu Key Laboratory for Supramolecular Medical Materials and Applications, College of Life Sciences, Nanjing Normal University, Nanjing, People's Republic of China.
Nanotechnology ; 23(4): 045104, 2012 Feb 03.
Article em En | MEDLINE | ID: mdl-22222202
To enhance the therapeutic potential of etoposide (ETO), we devised a targeted drug delivery system (TDDS) of epidermal growth factor-chitosan-carboxyl single-walled carbon nanotubes-ETO (EGF/CHI/SWNT-COOHs/ETO) using modified SWNTs (m-SWNTs) as the carrier, EGF-functionalized SWNTs (f-SWNTs) as the targeted moiety and ETO as the drug. After SWNT-COOHs were conjugated with CHI (CHI/SWNT-COOHs/ETO), they displayed high solubility and stable dispersion in aqueous solution. The drug loading capacity was approximately 25-27%. The m-SWNTs and f-SWNTs had only slight cytotoxicity. ETO was released from EGF/CHI/SWNT-COOHs/ETO at low pH and taken up by tumour cells via adenosine triphosphate (ATP)-dependent endocytosis. The cell death induced by EGF/CHI/SWNT-COOHs/ETO was as much as 2.7 times that due to ETO alone. In summary, these results demonstrated that our TDDS had a greater anticancer effect than free ETO in vitro.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanotubos de Carbono / Fator de Crescimento Epidérmico / Etoposídeo Limite: Humans Idioma: En Revista: Nanotechnology Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanotubos de Carbono / Fator de Crescimento Epidérmico / Etoposídeo Limite: Humans Idioma: En Revista: Nanotechnology Ano de publicação: 2012 Tipo de documento: Article