In vitro antiplasmodial properties of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae).
Afr J Tradit Complement Altern Med
; 8(1): 66-8, 2011.
Article
em En
| MEDLINE
| ID: mdl-22238485
ABSTRACT
The present study was conducted to investigate the in vitro antimalarial activity of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae). These two plants are used in Benin folk medicine to treat malaria and fever. Antimalarial activity was assayed on fresh clinical isolates of chloroquine resistant Plasmodium falciparum using the in vitro semi-microtest. The results revealed that the IC(50) varied from 1.55 to 22.36µg/ml. F. flavescens hydro methanol extract was more active than R. canthioides. The study demonstrated scientific rationale behind the traditional usage of these plants, however further bioactivity guided phytochemical analyses are necessary to identify the active principles.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Extratos Vegetais
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Malária Falciparum
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Rubiaceae
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Salicaceae
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Fitoterapia
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Antimaláricos
País/Região como assunto:
Africa
Idioma:
En
Revista:
Afr J Tradit Complement Altern Med
Ano de publicação:
2011
Tipo de documento:
Article