A revision of the organ radiation doses from 2-fluoro-2-deoxy-D-glucose with reference to tumour presence.
Radiat Prot Dosimetry
; 151(1): 43-50, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22247523
ABSTRACT
Absorbed radiation doses to major human organs after intravenous bolus administration of 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) were reviewed. Absorbed doses were calculated using the medical internal radiation dose (MIRD) formalism from experimental activity-time curves. Thirty patients (22 with macroscopic lung tumour and 8 without observable disease) were investigated using a state-of-the-art combined positron emission tomography/computer tomography system (Siemens Biograph 64). Each patient underwent a series of 10 consecutive whole-body PET scans during the first 60-min post-FDG administration. Differences were observed between organ radiation doses in this work and those reported in International Commission for Radiation Protection 106 (21 % in effective dose). The presence of tumour did not affect the FDG biodistribution. Large inter-individual variations in organ-absorbed doses were observed. This in combination with the lack of a model for bladder voiding suitable for all patients suggests the need for a more precise estimate of normal-organ radiation doses. This will be beneficial in optimising FDG administration in clinical routine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doses de Radiação
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Compostos Radiofarmacêuticos
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Fluordesoxiglucose F18
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Tomografia por Emissão de Pósitrons
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Neoplasias Pulmonares
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Radiat Prot Dosimetry
Ano de publicação:
2012
Tipo de documento:
Article