Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J Med Chem
; 55(4): 1662-70, 2012 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-22257165
ABSTRACT
The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously described biphenyl methylsulfone hydroxamate series, and they maintain superior Gram-negative antibacterial activity to comparator agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Ácidos Sulfônicos
/
Infecções por Bactérias Gram-Negativas
/
Amidoidrolases
/
Bactérias Gram-Negativas
/
Ácidos Hidroxâmicos
/
Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2012
Tipo de documento:
Article