Ethanol sensitivity in high drinking in the dark selectively bred mice.
Alcohol Clin Exp Res
; 36(7): 1162-70, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22316249
ABSTRACT
BACKGROUND:
Mouse lines are being selectively bred in replicate for high blood ethanol concentrations (BECs) achieved after a short period of ethanol (EtOH) drinking early in the circadian dark phase. High Drinking in the Dark-1 (HDID-1) mice were in selected generation S18, and the replicate HDID-2 line in generation S11.METHODS:
To determine other traits genetically correlated with high DID, we compared naïve animals from both lines with the unselected, segregating progenitor stock, HS/Npt. Differences between HDID-1 and HS would imply commonality of genetic influences on DID and these traits.RESULTS:
HDID-1 mice showed less basal activity, greater EtOH stimulated activity, and greater sensitivity to EtOH-induced foot slips than HS. They showed lesser sensitivity to acute EtOH hypothermia and longer duration loss of righting reflex than HS. HDID-1 and control HS lines did not differ in sensitivity on 2 measures of intoxication, the balance beam and the accelerating rotarod. None of the acute response results could be explained by differences in EtOH metabolism. HDID-2 differed from HS on some, but not all, of the above responses.CONCLUSIONS:
These results show that some EtOH responses share common genetic control with reaching high BECs after DID, a finding consistent with other data regarding genetic contributions to EtOH responses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cruzamento
/
Consumo de Bebidas Alcoólicas
/
Etanol
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Alcohol Clin Exp Res
Ano de publicação:
2012
Tipo de documento:
Article