Bromotheoynic acid, a brominated acetylenic acid from the marine sponge Theonella swinhoei.
Nat Prod Res
; 27(2): 117-22, 2013.
Article
em En
| MEDLINE
| ID: mdl-22324431
ABSTRACT
A new brominated C(17) acetylenic acid (1) designated as bromotheoynic acid has been isolated from the marine sponge Theonella swinhoei, collected off the coast of Tanegashima, Kagoshima Prefecture, Japan. The structure was determined on the basis of the analysis of its extensive 2D NMR spectroscopic data as well as HRMS. Bromotheoynic acid (1) inhibited maturation of starfish oocytes and cell division of fertilised starfish eggs. Bromotheoynic acid (1) also inhibited proliferation of human leukaemia U937 and HL60 cells, human lung cancer A549 and H1299 cells, and human embryonic kidney 293 (HEK293) cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Theonella
/
Alcinos
/
Ácidos Graxos Insaturados
/
Hidrocarbonetos Bromados
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2013
Tipo de documento:
Article