Model-based reconstruction integrated with fluence compensation for photoacoustic tomography.
IEEE Trans Biomed Eng
; 59(5): 1354-63, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22345521
ABSTRACT
Photoacoustic (PA) tomography (PAT) is a rapidly developing imaging modality that can provide high contrast and spatial-resolution images of light-absorption distribution in tissue. However, reconstruction of the absorption distribution is affected by nonuniform light fluence. This paper introduces a reconstruction method for reducing amplification of noise and artifacts in low-fluence regions. In this method, fluence compensation is integrated into model-based reconstruction, and the absorption distribution is iteratively updated. At each iteration, we calculate the residual between detected PA signals and the signals computed by a forward model using the initial pressure, which is the product of estimated voxel value and light fluence. By minimizing the residual, the reconstructed values converge to the true absorption distribution. In addition, we developed a matrix compression method for reducing memory requirements and accelerating reconstruction speed. The results of simulation and phantom experiments indicate that the proposed method provides a better contrast-to-noise ratio (CNR) in low-fluence regions. We expect that the capability of increasing imaging depth will broaden the clinical applications of PAT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
/
Processamento de Sinais Assistido por Computador
/
Tomografia
/
Técnicas Fotoacústicas
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Ano de publicação:
2012
Tipo de documento:
Article