Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.
Biomed Chromatogr
; 26(8): 942-61, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22354834
ABSTRACT
Fexofenadine (FEX) has been extensively used for therapeutic benefits after the market withdrawal of terfenadine. Recently, the popularity of FEX has emerged owing to its unique disposition via drug transporters and, hence, it has been used as a model probe for both in vitro and in vivo investigations to understand mechanistic aspects of drug-drug interactions (DDI). Going hand in hand with the increased use of FEX in therapy and research, numerous bioanalytical methods for FEX have been published. The various published bioanalytical methods for FEX are collated in this review to provide a comprehensive information on extraction methodology, assay conditions, chromatography and detection systems. Generally, the published methods have been adequately validated and can be readily used to support the use of FEX in pharmcokinetic, DDI and mechanistic investigations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Líquida
/
Terfenadina
/
Espectrometria de Massas em Tandem
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomed Chromatogr
Ano de publicação:
2012
Tipo de documento:
Article