Vascular hyperpermeability, angiogenesis, and stroma generation.
Cold Spring Harb Perspect Med
; 2(2): a006544, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22355795
ABSTRACT
It has been known for more than half a century that the tumor microvasculature is hyperpermeable to plasma proteins. However, the identity of the leaky vessels and the consequences of vascular hyperpermeability have received little attention. This article places tumor vascular hyperpermeability in a broader context, relating it to (1) the low-level "basal" permeability of the normal vasculature; (2) the "acute," short-term hyperpermeability induced by vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) and other vascular permeabilizing agents; and (3) the "chronic" hyperpermeability associated with longer-term exposure to agents such as VPF/VEGF-A that accompanies many types of pathological angiogenesis. Leakage of plasma protein-rich fluids is important because it activates the clotting system, depositing an extravascular fibrin gel provisional matrix that serves as the first step in stroma generation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade Capilar
/
Células Estromais
/
Neoplasias
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2012
Tipo de documento:
Article