IgE⺠memory B cells and plasma cells generated through a germinal-center pathway.
Nat Immunol
; 13(4): 396-404, 2012 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-22366892
ABSTRACT
Immunoglobulin E (IgE) antibodies are pathogenic in asthma and allergic diseases, but the in vivo biology of IgE-producing (IgE(+)) cells is poorly understood. A model of the differentiation of IgE(+) B cells proposes that IgE(+) cells develop through a germinal-center IgG1(+) intermediate and that IgE memory resides in the compartment of IgG1(+) memory B cells. Here we have used a reporter mouse expressing green fluorescent protein associated with membrane IgE transcripts (IgE-GFP) to assess in vivo IgE responses. In contrast to the IgG1-centered model of IgE switching and memory, we found that IgE(+) cells developed through a germinal-center IgE(+) intermediate to form IgE(+) memory B cells and plasma cells. Our studies delineate a new model for the in vivo biology of IgE switching and memory.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Imunoglobulina E
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Linfócitos B
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Diferenciação Celular
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Centro Germinativo
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Memória Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Immunol
Ano de publicação:
2012
Tipo de documento:
Article