Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US.
PLoS One
; 7(2): e32739, 2012.
Article
em En
| MEDLINE
| ID: mdl-22389721
ABSTRACT
Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8-12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full-length genomic sequence (7839 nt) of one feline NoV, CU081210E/2010/US, was determined. In the capsid protein VP1 region, the virus displayed the highest amino acid identity to animal genogroup IV genotype 2 (GIV.2) NoVs lion/Pistoia-387/06/IT (97.9%) and dog/Bari-170/07/IT (90.4%). These findings document the discovery of a novel feline calicivirus, different from vesiviruses, and extend the spectrum of NoV host range. Epidemiological studies using feline NoV-specific diagnostic tools and experimental infection of cats are required to understand whether NoVs have a pathogenic role in this species.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gatos
/
Genoma Viral
/
Infecções por Caliciviridae
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Norovirus
/
Gastroenterite
Limite:
Animals
Idioma:
En
Revista:
PLoS One
Ano de publicação:
2012
Tipo de documento:
Article