Immunohistochemical expression of anti-CD68 antibody in atherosclerotic plaque.
Rom J Morphol Embryol
; 53(1): 61-6, 2012.
Article
em En
| MEDLINE
| ID: mdl-22395501
UNLABELLED: Inflammation of the vascular wall is an essential event in the development of atherosclerosis, the main leukocytes of the inflammatory infiltrate being the monocyte/macrophages. These cells are very heterogeneous and rapidly change their function in response to signals received from the local environment. PURPOSE: The aim of this research was to study the immunohistochemical expression of the anti-CD68 antibody at the level of the atherosclerotic plaque. MATERIALS AND METHODS: We used tissue samples obtained by endarterectomies in patients with symptomatic atherosclerotic lesions. Inflammatory reaction was highlighted in the arterial wall by immunohistochemistry using an anti-CD68 monoclonal antibody that marks normal or pathological monocytes/macrophages. RESULTS AND DISCUSSION: The types of analyzed atherosclerotic lesions showed a positive reaction with the anti-CD68 antibody, varying in distribution and intensity in the vascular intima. The CD68 was positive in macrophages depending on the extent of the inflammatory reaction. CONCLUSIONS: The presence of many macrophages in the atherosclerotic plaques indicates a chronic inflammatory reaction, accompanied by fibroblast proliferation and connective tissue changes that influence the stability of the plaques.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imuno-Histoquímica
/
Antígenos de Diferenciação Mielomonocítica
/
Antígenos CD
/
Regulação da Expressão Gênica
/
Túnica Íntima
/
Placa Aterosclerótica
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Rom J Morphol Embryol
Ano de publicação:
2012
Tipo de documento:
Article