Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010.
Bull World Health Organ
; 90(2): 111-119D, 2012 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-22423162
ABSTRACT
OBJECTIVE:
To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010.METHODS:
Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys of a representative sample of TB patients or surveillance systems based on routine drug susceptibility testing. Associations between multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection and sex were explored through logistic regression.FINDINGS:
In 2007-2010, 80 countries and 8 territories reported surveillance data. MDR-TB among new and previously treated cases was highest in the Russian Federation (Murmansk oblast, 28.9%) and the Republic of Moldova (65.1%), respectively. In three former Soviet Union countries and South Africa, more than 10% of the cases of MDR-TB were extensively drug-resistant. Globally, in 1994 to 2010 multidrug resistance was observed in 3.4% (95% confidence interval, CI 1.9-5.0) of all new TB cases and in 19.8% (95% CI 14.4-25.1) of previously treated TB cases. No overall associations between MDR-TB and HIV infection (odds ratio, OR 1.4; 95% CI 0.7-3.0) or sex (OR 1.1; 95% CI 0.8-1.4) were found. Between 1994 and 2010, MDR-TB rates in the general population increased in Botswana, Peru, the Republic of Korea and declined in Estonia, Latvia and the United States of America.CONCLUSION:
The highest global rates of MDR-TB ever reported were documented in 2009 and 2010. Trends in MDR-TB are still unclear in most settings. Better surveillance or survey data are required, especially from Africa and India.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Vigilância da População
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Tuberculose Resistente a Múltiplos Medicamentos
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Farmacorresistência Bacteriana Múltipla
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Antituberculosos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Aspecto:
Equity_inequality
/
Patient_preference
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Bull World Health Organ
Ano de publicação:
2012
Tipo de documento:
Article