Caffeic acid oligomers with hyaluronidase inhibitory activity from Clinopodium gracile.
Chem Pharm Bull (Tokyo)
; 60(4): 499-507, 2012.
Article
em En
| MEDLINE
| ID: mdl-22466733
ABSTRACT
Eight new caffeic acid oligomers, clinopodic acids J-Q (1-8), were isolated from whole plants of Clinopodium gracile, together with nine known caffeic acid oligomers. The caffeic acid oligomers with two to four dihydrobenzofuran rings were isolated as natural products for the first time. Clinopodic acid M (4) showed the strongest hyaluronidase inhibitory activity, IC(50) (19 µM) among the 22 compounds isolated from this plant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Cafeicos
/
Lamiaceae
/
Inibidores Enzimáticos
/
Hialuronoglucosaminidase
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2012
Tipo de documento:
Article