Three different KRAS statuses in three synchronous colorectal cancers.
Med Oncol
; 29(4): 2864-5, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22467075
ABSTRACT
Treatments with monoclonal antibodies targeting the epidermal growth factor receptors (EGFR) have improved the prognosis of metastatic colorectal cancer (CRC). Mutated KRAS status is predictive of resistance to anti-EGFR agents and allows the selection of KRAS wild-type patients who may benefit from these targeted therapies. We report an original case of metastatic CRC including three synchronous primary tumors with three different KRAS statuses. We discuss the possible therapeutic impact of this clinical case and the role of multiple samplings for KRAS status determination.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Proteínas Proto-Oncogênicas
/
Proteínas ras
/
Mutação
/
Neoplasias Primárias Múltiplas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Med Oncol
Ano de publicação:
2012
Tipo de documento:
Article