A reverse genetics approach to study feline infectious peritonitis.
J Virol
; 86(12): 6994-8, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22491466
ABSTRACT
Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence analyses from FIP-diseased cats revealed that the 3c gene stop codon of strain 79-1146 has changed to restore a full-length open reading frame (ORF).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peritonite Infecciosa Felina
/
Coronavirus Felino
/
Genética Reversa
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
2012
Tipo de documento:
Article