Early echocardiographic prediction of ductal closure in neonates ≤ 30 weeks gestation.
J Perinatol
; 33(1): 45-51, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-22499084
ABSTRACT
OBJECTIVE:
To determine the accuracy of the patent ductus arteriosusleft pulmonary artery ratio (PDALPA) on echocardiogram (ECHO) at 3-day postnatal in predicting spontaneous PDA closure in neonates ≤ 30 weeks gestational age (GA). STUDYDESIGN:
ECHOs were performed at 72 h to characterize PDA size as closed-to-small (PDALPA <0.5) or moderate-to-large (PDALPA ≥ 0.5) and at 10 days to determine spontaneous closure (defined as closed-to-small in the absence of medical and/or surgical treatment). Caretakers were blinded to results; treatment was based on standard care. Neonates were prospectively enrolled and stratified <27 weeks (n=31) and 27 to 30 weeks (n=65).RESULT:
Neonates <27 weeks with closed-to-small PDAs had 60% spontaneous closure vs 9% when moderate-to-large (positive predictive value (PPV) 60%, negative predictive value (NPV) 91%). Neonates 27 to 30 weeks had 95% spontaneous closure vs 27%, respectively (PPV 95%, NPV 73%). Inter-observer variability for the initial ECHO was 0.84.CONCLUSION:
PDA size defined by PDALPA at 3 days postnatal in combination with GA predicts spontaneous PDA closure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ecocardiografia
/
Permeabilidade do Canal Arterial
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Recém-Nascido de Peso Extremamente Baixo ao Nascer
/
Doenças do Prematuro
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
/
Newborn
Idioma:
En
Revista:
J Perinatol
Ano de publicação:
2013
Tipo de documento:
Article