Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins.
Angew Chem Int Ed Engl
; 51(20): 4860-3, 2012 May 14.
Article
em En
| MEDLINE
| ID: mdl-22505324
ABSTRACT
Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Polissacarídeos
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Ácidos Siálicos
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Influenza Humana
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Influenza Aviária
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Hemaglutininas
Limite:
Animals
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Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2012
Tipo de documento:
Article