NMDAR2B tyrosine phosphorylation is involved in thermal nociception.
Neurosci Lett
; 516(2): 270-3, 2012 May 16.
Article
em En
| MEDLINE
| ID: mdl-22516462
ABSTRACT
Previous studies found that the NMDA receptor-mediated signaling regulates thermal nociception, though the underlying molecular mechanism remains unclear. The GluN2B subunit of the NMDA receptor is tyrosine-phosphorylated, Tyr-1472 being the major phosphorylation site. In this study, we have found that homozygous knock-in mice that express a Tyr-1472-Phe mutant of GluN2B display defects in the nociceptive response in the hot plate test. Expression of the neurotensin receptor subtype 2 (NTSR2), which is relevant to the regulation of thermal nociception, is decreased in the amygdala of GluN2B Tyr-1472-Phe knock-in mice. In addition, NTSR2-mediated c-fos induction is impaired in the amygdala of these mice. These data suggest that Tyr-1472 phosphorylation on GluN2B is involved in thermal nociception through regulating the NTSR2 mRNA expression in the amygdala.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de N-Metil-D-Aspartato
/
Receptores de Neurotensina
/
Nociceptividade
/
Tonsila do Cerebelo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2012
Tipo de documento:
Article