Comparison of the effectiveness of two protocols for vaccination (standard and double dosage) against hepatitis B virus in patients with inflammatory bowel disease.
Aliment Pharmacol Ther
; 35(12): 1379-85, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22530631
ABSTRACT
BACKGROUND:
The response rate to hepatitis B virus (HBV) vaccination in patients with inflammatory bowel disease (IBD) is low.AIM:
To compare two vaccination protocols-the standard dose and the double dose-in IBD patients.METHODS:
Patients diagnosed with IBD from three tertiary hospitals were vaccinated against HBV with two different protocols the standard protocol (Engerix-B single dose at 0, 1 and 6 months) and the new faster protocol based on a double dose (Engerix B double dose at 0, 1 and 2 months). Anti-HBs titres were measured 1-3 months after the last dose. A multivariate analysis was performed to identify factors that were predictive of response to the vaccine.RESULTS:
The study sample comprised 148 patients (mean age 40 years, 69% Crohn's disease), 70% of whom were receiving immunosuppressive therapy (22% thiopurines, 23% anti-TNF and 25% both). The standard protocol was followed in 46% of patients and the double dose protocol in 54%. Considering anti-HBs >10 IU/L as a successful response to vaccination, the seroconversion rate was higher among patients vaccinated with the double dose than with the standard dose 75% (95% CI, 65-85%) vs. 41% (95% CI, 29-54%) (P < 0.001). In the multivariate analysis, vaccination with the double dose was the only factor associated with a better response to the vaccine (OR, 4; 95% CI, 2-8; P < 0.001).CONCLUSIONS:
The response rate to the HBV vaccination in IBD patients is low. Administration of a double dose was associated with a higher response rate. Therefore, the double dose protocol could be a suitable option in patients with IBD.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
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Vírus da Hepatite B
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Vacinação
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Vacinas contra Hepatite B
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Hepatite B
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Imunossupressores
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Adult
/
Female
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Humans
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Male
Idioma:
En
Revista:
Aliment Pharmacol Ther
Ano de publicação:
2012
Tipo de documento:
Article